HIGH chromosome_number_variation HIGH exon_loss_variant HIGH frameshift_variant HIGH rare_amino_acid_variant HIGH splice_acceptor_variant HIGH splice_donor_variant HIGH start_lost HIGH stop_gained HIGH stop_lost HIGH transcript_ablation MODERATE 3_prime_UTR_truncation +exon_loss MODERATE 5_prime_UTR_truncation +exon_loss_variant MODERATE coding_sequence_variant MODERATE disruptive_inframe_deletion MODERATE disruptive_inframe_insertion MODERATE inframe_deletion MODERATE inframe_insertion MODERATE missense_variant MODERATE regulatory_region_ablation MODERATE splice_region_variant MODERATE TFBS_ablation LOW 5_prime_UTR_premature start_codon_gain_variant LOW initiator_codon_variant LOW splice_region_variant LOW start_retained LOW stop_retained_variant LOW synonymous_variant MODIFIER 3_prime_UTR_variant MODIFIER 5_prime_UTR_variant MODIFIER coding_sequence_variant MODIFIER conserved_intergenic_variant MODIFIER conserved_intron_variant MODIFIER downstream_gene_variant MODIFIER exon_variant MODIFIER feature_elongation MODIFIER feature_truncation MODIFIER gene_variant MODIFIER intergenic_region MODIFIER intragenic_variant MODIFIER intron_variant MODIFIER mature_miRNA_variant MODIFIER miRNA MODIFIER NMD_transcript_variant MODIFIER non_coding_transcript_exon_variant MODIFIER non_coding_transcript_variant MODIFIER regulatory_region_amplification MODIFIER regulatory_region_variant MODIFIER TF_binding_site_variant MODIFIER TFBS_amplification MODIFIER transcript_amplification MODIFIER transcript_variant MODIFIER upstream_gene_variant MODERATE conservative_inframe_insertion MODERATE conservative_inframe_deletion